Discovery Platform

Qualifying Pathobionts – Artizan Workflow

Our Discovery Platform

Artizan’s proprietary discovery platform involves methodically investigating microbial communities and individual bacterial strains from healthy and disease-affected people. Once a strain of interest is identified, Artizan applies its mechanistic research expertise to determine the root causes of pathology. Deciphering pathogenic mechanisms helps us pursue disease-modifying therapeutic strategies.

What is a Pathobiont?

Pathobionts are organisms with pathogenic potential that can cause or promote disease under specific genetic or environmental conditions but may otherwise be benign.

Disease results from a combination of host genetics and the gut microbiota, influenced by environmental factors

Unsusceptible person
+
lacking in “pathobiont”
=
healthy person

Person is clear of pathobiont and genetic susceptibility.

Unsusceptible person
+
“pathobiont”
=
healthy person

Pathobiont may be present at low abundance and/or person is not susceptible to pathogenic mechanism.

Susceptible person
+
lacking in “pathobiont”
=
healthy person or disease independent of pathobiont

Susceptible person may remain healthy or develop disease unrelated to pathobiont.

Susceptible person
+
“pathobiont”
=
foundation for inflammatory disorder

Susceptible person colonized with pathobiont creates the foundation for inflammatory disease.